In Cambodia, Lao PDR, Thailand, Myanmar and Viet Nam, optimal economic investment potential for cities and towns at most cross-border economic zones is not realized. After investigating and evaluating the potential of 17 border crossings (corresponding to 34 border towns) along economic corridors, we identified four border crossings between China/Vietnam, Cambodia/Thailand and Lao PDR/Thailand, for which strategic economic plans are being developed. The plans will set specific policies and proposals to optimize investment opportunities, upgrade economic zone performance and create a better socio-economic climate in the associated small cities and towns.